abstract：UNLABELLED:Biofilm formation is responsible for increased antibiotic tolerance in pathogenic bacteria. Cyclic di-GMP (c-di-GMP) is a widely used second-messenger signal that plays a key role in bacterial biofilm formation. c-di-GMP is synthesized by diguanylate cyclases (DGCs), a conserved class of enzymes absent in ma...

journal_title：Journal of bacteriology

authors： Fernicola S,Paiardini A,Giardina G,Rampioni G,Leoni L,Cutruzzolà F,Rinaldo S

更新日期：2015-09-28 00:00:00

abstract：UNLABELLED:Resistance to methicillin and other β-lactam antibiotics in staphylococci is due to mecA, which is carried on a genomic island, staphylococcal cassette chromosome mec (SCCmec). The chromosomal excision and integration of SCCmec are mediated by the site-specific recombinase CcrAB or CcrC, encoded within this ...

journal_title：Journal of bacteriology

authors： Wang L,Ahmed MH,Safo MK,Archer GL

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:During biosynthesis of [NiFe]-hydrogenase 2 (Hyd-2) of Escherichia coli, a 15-amino-acid C-terminal peptide is cleaved from the catalytic large subunit precursor, pro-HybC. This peptide is removed only after NiFe(CN)2CO cofactor insertion by the Hyp accessory protein machinery has been completed, suggesting ...

journal_title：Journal of bacteriology

authors： Thomas C,Muhr E,Sawers RG

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:Rhodobacter sphaeroides is a free-living alphaproteobacterium that contains two clusters of functional flagellar genes in its genome: one acquired by horizontal gene transfer (fla1) and one that is endogenous (fla2). We have shown that the Fla2 system is normally quiescent and under certain conditions produc...

journal_title：Journal of bacteriology

authors： de la Mora J,Uchida K,del Campo AM,Camarena L,Aizawa S,Dreyfus G

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:Pupylation is a posttranslational modification peculiar to actinobacteria wherein proteins are covalently modified with a small protein called the prokaryotic ubiquitin-like protein (Pup). Like ubiquitination in eukaryotes, this phenomenon has been associated with proteasome-mediated protein degradation in m...

journal_title：Journal of bacteriology

authors： Compton CL,Fernandopulle MS,Nagari RT,Sello JK

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:CbrA is an atypical sensor kinase found in Pseudomonas. The autokinase domain is connected to a putative transporter of the sodium/solute symporter family (SSSF). CbrA functions together with its cognate response regulator, CbrB, and plays an important role in nutrient acquisition, including regulation of hu...

journal_title：Journal of bacteriology

authors： Zhang XX,Gauntlett JC,Oldenburg DG,Cook GM,Rainey PB

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:All methanofuran structural variants contain a basic core structure of 4-[N-(γ-l-glutamyl)-p-(β-aminoethyl)phenoxymethyl]-(aminomethyl)furan (APMF-Glu) but have different side chains depending on the source organism. Recently, we identified four genes (MfnA, MfnB, MfnC, and MfnD) that are responsible for the...

journal_title：Journal of bacteriology

authors： Wang Y,Xu H,Jones MK,White RH

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:Over the course of the last 3 decades the role of the second messenger cyclic di-GMP (c-di-GMP) as a master regulator of bacterial physiology was determined. Although the control over c-di-GMP levels via synthesis and breakdown and the allosteric regulation of c-di-GMP over receptor proteins (effectors) and ...

journal_title：Journal of bacteriology

authors： Rotem O,Nesper J,Borovok I,Gorovits R,Kolot M,Pasternak Z,Shin I,Glatter T,Pietrokovski S,Jenal U,Jurkevitch E

更新日期：2015-08-31 00:00:00

abstract：UNLABELLED:The ubiquitous bacterial second messenger cyclic di-GMP (c-di-GMP) has recently become prominent as a trigger for biofilm formation in many bacteria. It is generated by diguanylate cyclases (DGCs; with GGDEF domains) and degraded by specific phosphodiesterases (PDEs; containing either EAL or HD-GYP domains)....

journal_title：Journal of bacteriology

authors： Povolotsky TL,Hengge R

更新日期：2015-08-24 00:00:00

abstract：UNLABELLED:The transmembrane Tsr protein of Escherichia coli mediates chemotactic responses to environmental serine gradients. Serine binds to the periplasmic domain of the homodimeric Tsr molecule, promoting a small inward displacement of one transmembrane helix (TM2). TM2 piston displacements, in turn, modulate the s...

journal_title：Journal of bacteriology

authors： Kitanovic S,Ames P,Parkinson JS

更新日期：2015-08-01 00:00:00

abstract：UNLABELLED:Bacterial type IV coupling proteins (T4CPs) bind and mediate the delivery of DNA substrates through associated type IV secretion systems (T4SSs). T4CPs consist of a transmembrane domain, a conserved nucleotide-binding domain (NBD), and a sequence-variable helical bundle called the all-alpha domain (AAD). In ...

journal_title：Journal of bacteriology

authors： Whitaker N,Chen Y,Jakubowski SJ,Sarkar MK,Li F,Christie PJ

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:The role of chromosomal toxin-antitoxin (TA) systems, which are ubiquitous within the genomes of free-living bacteria, is still debated. We have scanned the Vibrio cholerae N16961 genome for class 2 TA genes and identified 18 gene pair candidates. Interestingly, all but one are located in the chromosome 2 su...

journal_title：Journal of bacteriology

authors： Iqbal N,Guérout AM,Krin E,Le Roux F,Mazel D

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:Many bacteria produce secreted iron chelators called siderophores, which can be shared among cells with specific siderophore uptake systems regardless of whether the cell produces siderophores. Sharing secreted products allows freeloading, where individuals use resources without bearing the cost of productio...

journal_title：Journal of bacteriology

authors： Scholz RL,Greenberg EP

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:The airways of patients with cystic fibrosis are colonized with diverse bacterial communities that change dynamically during pediatric years and early adulthood. Staphylococcus aureus is the most prevalent pathogen during early childhood, but during late teens and early adulthood, a shift in microbial compos...

journal_title：Journal of bacteriology

authors： Filkins LM,Graber JA,Olson DG,Dolben EL,Lynd LR,Bhuju S,O'Toole GA

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:The 2-thiouridine (s(2)U) modification of the wobble position in glutamate, glutamine, and lysine tRNA molecules serves to stabilize the anticodon structure, improving ribosomal binding and overall efficiency of the translational process. Biosynthesis of s(2)U in Escherichia coli requires a cysteine desulfur...

journal_title：Journal of bacteriology

authors： Black KA,Dos Santos PC

更新日期：2015-06-01 00:00:00

abstract：:Lipoprotein biogenesis in Gram-negative bacteria occurs by a conserved pathway, each step of which is considered essential. In contrast to this model, LoVullo and colleagues demonstrate that the N-acyl transferase Lnt is not required in Francisella tularensis or Neisseria gonorrhoeae. This suggests the existence of a ...

journal_title：Journal of bacteriology

authors： Chahales P,Thanassi DG

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:Campylobacter jejuni is a leading cause of bacterial diarrheal disease and a frequent commensal of the intestinal tract in poultry and other animals. For optimal growth and colonization of hosts, C. jejuni employs two-component regulatory systems (TCSs) to monitor environmental conditions and promote proper ...

journal_title：Journal of bacteriology

authors： Luethy PM,Huynh S,Parker CT,Hendrixson DR

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:Misincorporation of D-tyrosine (D-Tyr) into cellular proteins due to mischarging of tRNA(Tyr) with D-Tyr by tyrosyl-tRNA synthetase inhibits growth and biofilm formation of Bacillus subtilis. Furthermore, many B. subtilis strains lack a functional gene encoding D-aminoacyl-tRNA deacylase, which prevents misi...

journal_title：Journal of bacteriology

authors： Williams-Wagner RN,Grundy FJ,Raina M,Ibba M,Henkin TM

更新日期：2015-05-01 00:00:00

abstract：:Recombinant Ralstonia eutropha strain PHB(-)4 expressing the broad-substrate-specificity polyhydroxyalkanoate (PHA) synthase 1 from Pseudomonas sp. strain 61-3 (PhaC1Ps) synthesizes a PHA copolymer containing the branched side-chain unit 3-hydroxy-4-methylvalerate (3H4MV), which has a carbon backbone identical to that...

journal_title：Journal of bacteriology

authors： Saika A,Ushimaru K,Mizuno S,Tsuge T

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:Ileal lesions of patients with Crohn's disease are colonized by adherent-invasive Escherichia coli (AIEC), which is able to adhere to and to invade intestinal epithelial cells (IEC), to replicate within macrophages, and to form biofilms on the surface of the intestinal mucosa. Previous analyses indicated the...

journal_title：Journal of bacteriology

authors： Chassaing B,Garénaux E,Carriere J,Rolhion N,Guérardel Y,Barnich N,Bonnet R,Darfeuille-Michaud A

更新日期：2015-04-01 00:00:00

abstract：:Thiamine pyrophosphate (TPP), the biologically active form of thiamine (also known as vitamin B1), is an essential cofactor for several important enzymes involved in carbohydrate metabolism, and therefore, it is required for all living organisms. We recently found that a thiamine-binding protein (TDE_0143) is essentia...

journal_title：Journal of bacteriology

authors： Bian J,Tu Y,Wang SM,Wang XY,Li C

更新日期：2015-04-01 00:00:00

abstract：:Horizontal gene transfer by conjugation plays a major role in bacterial evolution, allowing the acquisition of new traits, such as virulence and resistance to antibacterial agents. With the increased antibiotic resistance in bacterial pathogens, a better understanding of how bacteria modulate conjugation under changin...

journal_title：Journal of bacteriology

authors： Grace ED,Gopalkrishnan S,Girard ME,Blankschien MD,Ross W,Gourse RL,Herman C

更新日期：2015-03-01 00:00:00

abstract：:The O polysaccharide of the lipopolysaccharide (O antigen) of Gram-negative bacteria often serves as a receptor for bacteriophages that can make the phage dependent on a given O-antigen type, thus supporting the concept of the adaptive significance of the O-antigen variability in bacteria. The O-antigen layer also mod...

journal_title：Journal of bacteriology

authors： Knirel YA,Prokhorov NS,Shashkov AS,Ovchinnikova OG,Zdorovenko EL,Liu B,Kostryukova ES,Larin AK,Golomidova AK,Letarov AV

更新日期：2015-03-01 00:00:00

abstract：:The anaerobic pathogen Clostridium perfringens encodes either toxin genes or antibiotic resistance determinants on a unique family of conjugative plasmids that have a novel conjugation region, the tcp locus. Studies of the paradigm conjugative plasmid from C. perfringens, the 47-kb tetracycline resistance plasmid pCW3...

journal_title：Journal of bacteriology

authors： Wisniewski JA,Teng WL,Bannam TL,Rood JI

更新日期：2015-02-15 00:00:00

abstract：:The metabolism of one- and two-carbon compounds by the methylotrophic bacterium Methylobacterium extorquens AM1 involves high carbon flux through the ethylmalonyl coenzyme A (ethylmalonyl-CoA) pathway (EMC pathway). During growth on ethylamine, the EMC pathway operates as a linear pathway carrying the full assimilator...

journal_title：Journal of bacteriology

authors： Good NM,Martinez-Gomez NC,Beck DA,Lidstrom ME

更新日期：2015-02-15 00:00:00

abstract：:Bacteria form communities, termed biofilms, in which cells adhere to each other within a matrix, typically comprised of polysaccharides, proteins, and extracellular DNA. Biofilm formation by the marine bacterium Vibrio fischeri requires the Syp polysaccharide, but the involvement of matrix proteins is as yet unknown. ...

journal_title：Journal of bacteriology

authors： Ray VA,Driks A,Visick KL

更新日期：2015-02-01 00:00:00

abstract：:Germination of Bacillus subtilis spores is normally initiated when nutrients from the environment interact with germinant receptors (GRs) in the spores' inner membrane (IM), in which most of the lipids are immobile. GRs and another germination protein, GerD, colocalize in the IM of dormant spores in a small focus term...

journal_title：Journal of bacteriology

authors： Troiano AJ Jr,Zhang J,Cowan AE,Yu J,Setlow P

更新日期：2015-01-01 00:00:00

abstract：:Interest in finding small RNAs (sRNAs) in bacteria has significantly increased in recent years due to their regulatory functions. Development of high-throughput methods and more sophisticated computational algorithms has allowed rapid identification of sRNA candidates in different species. However, given their various...

journal_title：Journal of bacteriology

authors： Tsai CH,Liao R,Chou B,Palumbo M,Contreras LM

更新日期：2015-01-01 00:00:00

abstract：:The nucleotide second messengers pppGpp and ppGpp [(p)ppGpp] are responsible for the global downregulation of transcription, translation, DNA replication, and growth rate that occurs during the stringent response. More recent studies suggest that (p)ppGpp is also an important effector in many nonstringent processes, i...

journal_title：Journal of bacteriology

authors： Ababneh QO,Herman JK

更新日期：2015-01-01 00:00:00

abstract：:Bacteriocin 41 (Bac41) is produced from clinical isolates of Enterococcus faecalis and consists of two extracellular proteins, BacL1 and BacA. We previously reported that BacL1 protein (595 amino acids, 64.5 kDa) is a bacteriolytic peptidoglycan D-isoglutamyl-L-lysine endopeptidase that induces cell lysis of E. faecal...

journal_title：Journal of bacteriology

authors： Kurushima J,Nakane D,Nishizaka T,Tomita H

更新日期：2015-01-01 00:00:00

abstract：:Bacillus anthracis, the causative agent of anthrax, replicates as chains of vegetative cells by regulating the separation of septal peptidoglycan. Surface (S)-layer proteins and associated proteins (BSLs) function as chain length determinants and bind to the secondary cell wall polysaccharide (SCWP). In this study, we...

journal_title：Journal of bacteriology

authors： Liszewski Zilla M,Chan YG,Lunderberg JM,Schneewind O,Missiakas D

更新日期：2015-01-01 00:00:00

abstract：:Staphylococcus aureus responds to changing extracellular environments in part by adjusting its proteome through alterations of transcriptional priorities and selective degradation of the preexisting pool of proteins. In Bacillus subtilis, the proteolytic adaptor protein MecA has been shown to play a role in assisting ...

journal_title：Journal of bacteriology

authors： Donegan NP,Marvin JS,Cheung AL

更新日期：2014-12-01 00:00:00

abstract：:The polysaccharide intercellular adhesin or the cell wall-anchored accumulation-associated protein (Aap) mediates cellular accumulation during Staphylococcus epidermidis biofilm maturation. Mutation of sortase, which anchors up to 11 proteins (including Aap) to the cell wall, blocked biofilm development by the cerebro...

journal_title：Journal of bacteriology

authors： Conlon BP,Geoghegan JA,Waters EM,McCarthy H,Rowe SE,Davies JR,Schaeffer CR,Foster TJ,Fey PD,O'Gara JP

更新日期：2014-12-01 00:00:00

abstract：:The ubiquitous opportunistic pathogen Pseudomonas aeruginosa has five aerobic terminal oxidases: bo(3)-type quinol oxidase (Cyo), cyanide-insensitive oxidase (CIO), aa3-type cytochrome c oxidase (aa3), and two cbb(3)-type cytochrome c oxidases (cbb(3)-1and cbb(3)-2). These terminal oxidases are differentially regulate...

journal_title：Journal of bacteriology

authors： Arai H,Kawakami T,Osamura T,Hirai T,Sakai Y,Ishii M

更新日期：2014-12-01 00:00:00

abstract：:Caldicellulosiruptor bescii efficiently degrades cellulose, xylan, and native grasses at high temperatures above 70°C under anaerobic conditions. C. bescii extracellularly secretes multidomain glycoside hydrolases along with proteins of unknown function. In this study, we analyzed the C. bescii proteins that bind to t...

journal_title：Journal of bacteriology

authors： Yokoyama H,Yamashita T,Morioka R,Ohmori H

更新日期：2014-11-01 00:00:00

abstract：:The mechanisms involved in the virulence of Yersinia pestis, the plague pathogen, are not fully understood. In previous research, we found that a Y. pestis mutant lacking the HicB3 (YPO3369) putative orphan antitoxin was attenuated for virulence in a murine model of bubonic plague. Toxin-antitoxin systems (TASs) are w...

journal_title：Journal of bacteriology

authors： Bibi-Triki S,Li de la Sierra-Gallay I,Lazar N,Leroy A,Van Tilbeurgh H,Sebbane F,Pradel E

更新日期：2014-11-01 00:00:00

abstract：:To elucidate the biological functions of the ribosomal protein L34, which is encoded by the rpmH gene, the rpmH deletion mutant of Bacillus subtilis and two suppressor mutants were characterized. Although the ΔrpmH mutant exhibited a severe slow-growth phenotype, additional mutations in the yhdP or mgtE gene restored ...

journal_title：Journal of bacteriology

authors： Akanuma G,Kobayashi A,Suzuki S,Kawamura F,Shiwa Y,Watanabe S,Yoshikawa H,Hanai R,Ishizuka M

更新日期：2014-11-01 00:00:00

abstract：:Despite the considerable knowledge of bacterial high-molecular-weight (HMW) polycyclic aromatic hydrocarbon (PAH) metabolism, the key enzyme(s) and its pleiotropic and epistatic behavior(s) responsible for low-molecular-weight (LMW) PAHs in HMW PAH-metabolic networks remain poorly understood. In this study, a phenotyp...

journal_title：Journal of bacteriology

authors： Kweon O,Kim SJ,Kim DW,Kim JM,Kim HL,Ahn Y,Sutherland JB,Cerniglia CE

更新日期：2014-10-01 00:00:00

abstract：:The nitrogenase gene cluster in cyanobacteria has been thought to comprise multiple operons; however, in Anabaena variabilis, the promoter for the first gene in the cluster, nifB1, appeared to be the primary promoter for the entire nif cluster. The structural genes nifHDK1 were the most abundant transcripts; however, ...

journal_title：Journal of bacteriology

authors： Pratte BS,Thiel T

更新日期：2014-10-01 00:00:00

abstract：:Bacterial uptake of phosphate is usually accomplished via high-affinity transporters that are commonly regulated by two-component systems, which are activated when the concentration of phosphate is low. Mycobacterium smegmatis possesses two such transporters, the widely distributed PstSCAB system and PhnDCE, a transpo...

journal_title：Journal of bacteriology

authors： Gebhard S,Busby JN,Fritz G,Moreland NJ,Cook GM,Lott JS,Baker EN,Money VA

更新日期：2014-10-01 00:00:00